Staphylococcus Lugdunensis Prosthetic Joint Infection: a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Description of patients with PJI infection due to Staphylococcus lugdunensis : surgical treatment
研究概览
简要总结
Staphylococcus lugdunensis is a coagulase-negative staphylococcus belonging to the human commensal cutaneous flora, and has been little studied in the field of prosthetic joint infections. However, it shares many virulence traits with Staphylococcus aureus, including many adhesins and its ability to form biofilm, and the few series of cases reports a significant failure rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •infection of joint prosthesis (whatever its type) with Staphylococcus lugdunensis defined by the positivity of at least 2 gold-standard samples (joint puncture, intraoperative samples) with S. lugdunensis; OR
- •a single positive gold-standard sample or positive blood cultures AND formal clinical, radiological, biological and / or pathological arguments in favor of an infection of joint prosthesis AND absence of other pathogenic agent
排除标准
- 未提供
结局指标
主要结局
Description of patients with PJI infection due to Staphylococcus lugdunensis : surgical treatment
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
description of surgery performed : DAIR, one-step exchange, two-step exchange
Rate of PJI infection with Staphylococcus lugdunensis
时间窗: between 2010 and 2020
proportion of patients having PJI infection with Staphylococcus lugdunensis, alone or with other bacteria
Description of PJI infection with Staphylococcus lugdunensis : type
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
type of PJI : knee or hip prosthesis
Description of patients with PJI infection due to Staphylococcus lugdunensis : follow up
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
duration of the follow up of patients
Description of patients with PJI infection due to Staphylococcus lugdunensis : medical treatment
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
description and duration of antibiotics
Description of patients with PJI infection due to Staphylococcus lugdunensis
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
type of patients: age, CMI
Description of PJI infection with Staphylococcus lugdunensis : evolution
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
evolution of PJI :evolution between prosthesis placement and the onset of symptoms, gateway to infection
rate of treatment failure
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
次要结局
未报告次要终点