Acute Effects of Moderate Versus High Intensity Exercise on Insulin Sensitivity in Gestational Diabetes Mellitus

Not Applicable

Terminated

• Conditions: Diabetes, Gestational
• Interventions: Behavioral: exercise

• Registration Number: NCT01961401
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Exercise training is recognized as effective in preventing and treating many chronic metabolic disorders (1), and long-term exercise programmes have similar effects on glucose control as long-term drug or insulin therapy in type 2 diabetic patients (2). The precise intensity and volume of aerobic exercise needed to produce the most wanted effects on targeted risk factors for subjects at risk of/with established type 2 diabetes, is still uncertain. In this study the investigators will investigate the acute effects of a single bout of moderate versus high intensity exercise on insulin sensitivity in pregnant women with and without gestational diabetes mellitus (GDM). The investigators think that very short bouts of high intensity exercise can be a way to reduce blood glucose in these women.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-10-09
• Study First Submitted QC: 2013-10-10
• Study First Posted: 2013-10-11
• Primary Completion: 2018-02
• Study Completion: 2018-02
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-06
• Last Update Posted: 2018-04-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 9

Inclusion Criteria

• pregnant
• Gestational diabetes mellitus or normal glucose tolerance
• able to exercise

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High intensity exercise	exercise	High intensity, short duration exercise on bike
Moderate exercise	exercise	Moderate intensity exercise training on bike

Primary Outcome Measures

Name	Time	Method
insulin sensitivity	1 day	insulin sensitivity index, as described by Matsuda and DeFronzo. This calculation uses the fasting plasma glucose and plasma insulin, and the average plasma glucose and insulin values over the 30, 60, 90, and 120 minutes after an oral glucose tolerance test (OGTT), and is calculated as:. 10 000/√\[fasting glucose x fasting insulin) x (mean glucose during OGTT x mean insulin during OGTT)\]. We will use a carbohydrate rich meal instead of a classic oral glucose tolerance test with glucose in water.

Trial Locations

Locations (1)

Department of circulation and medical imaging; 🇳🇴 Trondheim, Norway