Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness

Not Applicable

Completed

• Conditions: General Anesthesia
• Interventions: Device: Diprifusor (Target-controlled infusion); Device: Orchestra (Target-controlled infusion)

• Registration Number: NCT01091350
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-05
• Primary Completion: 2009-10
• Study Completion: 2009-11
• Study First Submitted: 2010-03-14
• Study First Submitted QC: 2010-03-22
• Study First Posted: 2010-03-24
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-29
• Last Update Posted: 2013-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Adult patients undergoing general anesthesia

Exclusion Criteria

• Hepatic or renal disease
• Drug addiction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Diprifusor group	Diprifusor (Target-controlled infusion)	Propofol was infused via Diprifusor TCI (Target-controlled infusion)
Orchestra group	Orchestra (Target-controlled infusion)	Propofol was infused via Orchestra TCI

Primary Outcome Measures

Name	Time	Method
Estimated effect-site propofol concentration at loss of consciousness	after propofol infusion

Secondary Outcome Measures

Name	Time	Method
Time to loss of consciousness	after propofol infusion