ISRCTN37666216已完成未知
Adjunctive Rifampicin to Reduce Early mortality from STaphylococcus aureus bacteraemia: a multi-centre, randomised, double blind, placebo-controlled trial
Medical Research Council (MRC) (UK)0 个研究点目标入组 770 人开始时间: 2012年1月26日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 770
研究概览
简要总结
2012 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/23249501 2018 results in: http://www.ncbi.nlm.nih.gov/pubmed/30382016
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Adults (18 years or older)
- •2. Staphylococcus aureus (meticillin-susceptible or resistant) grown from at least one blood culture
- •3. Less than 96 hours of active antibiotic therapy for the current infection (added 09/11/2016: not including rifampicin and excluding stat doses)
- •4. Patient or legal representative (LR) provides written informed consent
排除标准
- •1. Infection not caused by S. aureus alone in the opinion of the treating physician (e.g. S. aureus is considered a blood culture contaminant, or polymicrobial culture with another organism likely to be contributing clinically to the current infection)
- •2. Sensitivity results already available and demonstrate rifampicin resistant S. aureus (defined by British Society for Antimicrobial Chemotherapy in vitro disc susceptibility testing)
- •3. Treating physician considers rifampicin is contraindicated for any reason
- •4. Treating physician considers rifampicin treatment is mandatory for any reason
- •5. Suspected active infection with Mycobacterium tuberculosis
- •6. Previously been randomised in ARREST for a prior episode of S. aureus bacteraemia
研究者
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