Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal

Not Applicable

Recruiting

• Conditions: Reading Disorder
• Interventions: Behavioral: Action Video-Game

• Registration Number: NCT06186882
• Lead Sponsor: IRCCS Eugenio Medea

Brief Summary

Developmental dyslexia affects 7% of school-age children (Male:Female ratio of 1.5:1) and incurs disadvantages in education and occupation. Scientific progress concerning the etiology of developmental dyslexia evidenced the complex gene-environment interaction. The DCDC2-READ1 deletion associates with reading skills and affects the magnocellular-dorsal stream in humans and animals. DCDC2 modifies neural activity within the excitatory pathways. The magnocellular-dorsal stream mediates the function of the attention network. Difficulties in spatial and temporal attention shifting impair letter-to-speech sound integration increasing neural noise. Action video games improve the efficiency of the magnocellular-dorsal stream. The aim of this cutting-edge, round trip translation study is threefold: 1.to unravel new insights behind the pathophysiology of developmental dyslexia, 2. to assess gene-environment interaction effects on developmental dyslexia endophenotypes, and 3. to identify useful clues to foster the identification of new, personalized treatments.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-30
• Study First Submitted: 2023-11-30
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-15
• Last Update Submitted: 2023-12-15
• Study First Posted: 2024-01-02
• Last Update Posted: 2024-01-02
• Primary Completion: 2026-04-30
• Study Completion: 2026-04-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

• intelligence quotient below the average range,
• presence of counter indications for magnetic resonance acquisition,
• previous diagnosis of any neurodevelopmental disorders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ENVIRONMENTAL STIMULATION	Action Video-Game	-

Primary Outcome Measures

Name	Time	Method
Rapid automatized naming	3 years	Rapid automatized naming - assessed by the RAN test. Measures obtained: Z scores age-corrected.
Short-term memory	3 years	Short-term memory - assessed by the Single Digit Forward Span, Single Digit Backward Span. Measures obtained: Z scores age-corrected.
Phonological awareness	3 years	Phonological awareness - assessed by the nonword repetition test. Measures obtained: Z scores age-corrected.
Visual motion processing	3 years	Visual motion processing - assessed by Coherent dot motion task
Reading skills	3 years	Reading skills - assessed by single unrelated words and pseudo-words reading tests. Measures obtained: Z scores age-corrected.
Visual attention	3 years	Visual attention - assessed by a computer-based visual attention task
measurement of neurotransmitters	3 years	in vivo measures of neurotransmitters including glutamate and gamma-Aminobutyric acid magnetic resonance spectroscopy

Trial Locations

Locations (1)

Scientific Institute IRCCS E Medea; 🇮🇹 Bosisio Parini, LC, Italy