L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

Phase 4

• Conditions: Thalassemia
• Interventions: Drug: L-arginine; Drug: Sildenafil

• Registration Number: NCT03402191
• Lead Sponsor: Sherief Abd-Elsalam

Brief Summary

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

Detailed Description

This study focuses on different lines of treatment for pulmonary hypertension in children with thalassemia as this study discusses the Effect of L-arginine Versus Sildenafil in Children with Beta Thalassemia Associated with Pulmonary Hypertension

Study Timeline

• Study Start: 2016-07
• Study First Submitted: 2018-01-09
• Study First Submitted QC: 2018-01-16
• Study First Posted: 2018-01-18
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-23
• Last Update Posted: 2018-08-27
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Children with thalassemia and pulmonary hypertension.

Exclusion Criteria

• Rheumatic heart diseases.
• Other comorbid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
L-arginine	L-arginine	l-arginine for pulmonary hypertension in patients with thalassemia.
Sildenafil	Sildenafil	Sildenafil for pulmonary hypertension in patients with thalassemia.

Primary Outcome Measures

Name	Time	Method
Number of patients with improvement of pulmonary hypertension	6 months	patients with improvement of pulmonary hypertension

Trial Locations

Locations (1)

Sherief Abd-Elsalam; 🇪🇬 Tanta, Egypt