Speech Intelligibility of Patients With Parkinsons Disease at Different Stages of the Disease Compared to First Degree Relatives of Parkinson's Disease Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Maximum phonation time
研究概览
简要总结
This study will examine speech intelligibility of early parkinson's disease (PD) patients, early PD patients and first degree relatives. The investigators hypothesis that advanced PD patients will present decreased speech intelligibility more than early PD patients. Speech intelligibility of first degree relatives will be normal.
详细描述
in order to achieve the study's goals objective and subjective research tools will be used.
Objective tools include measuring phonation time, diadokokinetic movements of the oral structures and acoustic analysis .
Subjective tools include self reported questionnaires.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Advanced PD patients
- •Early PD patients
- •First degree relatives
排除标准
- •Patients with decreased cognitive abilities
- •Patients who participate in speech therapy
结局指标
主要结局
Maximum phonation time
时间窗: DAY 1
maximum phonation time will be measured after taking few measurements of sentence reading.It is an observational study that aim to collect data during DAY 1 only! day 1 for outcome measure time frames There are not pre/post measurements
次要结局
- Diadokokinetik (DDK): production time of 10x PATAKA, 7x /P/ and 7x /t/(DAY 1)
研究者
Michal Roll PhD,MBA
director rnd devision
Tel-Aviv Sourasky Medical Center