ISRCTN47578325
Completed
Not Applicable
Evaluation of melatonin therapy on sleep and delirium in intensive care patients
Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)0 sites48 target enrollmentSeptember 12, 2003
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ervous System Diseases: Sleep disorders
- Sponsor
- Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients admitted to the adult general intensive care unit with acute respiratory failure requiring mechanical ventilation and then a tracheostomy to assist weaning.
Exclusion Criteria
- •1\. Expected length of stay of less than five further days
- •2\. Previously treated for sleep disturbances
- •3\. Not receiving target enteral feed volume or aspirates greater than 200mls
- •4\. Previous history of convulsions
- •5\. Psychiatric or neurological disease
- •6\. Excessive alcohol consumption (equal to or greater than 50 units per week)
- •7\. Recreational drug use
- •8\. Sleep apnoea
- •9\. Severe heart failure (NYHA III/ IV)
- •10\. Sedative infusions must have been discontinued for more than 24 hours (propofol and alfentanil) or more than 36 hours (morphine and midazolam) with a Sedation Agitation Score (SAS) \> 3
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Phase 3
The effect of melatonin on sleep disorders in children with cerebral palsyCondition 1: cerebral palsy. Condition 2: Sleep disorders.Spastic quadriplegic cerebral palsySleep disordersG80.0IRCT20191017045142N1Mashhad University of Medical Sciences50
Not yet recruiting
Phase 3
The Effects of Melatonin in Sleep Disorders of Sarcoidosis PatientsIRCT20151227025726N25Shahid Beheshti University of Medical Sciences100
Recruiting
Phase 3
Evaluation of the effect of melatonin in the treatment of problems caused by androgen deprivation therapy in prostate cancer patientsIRCT20180722040556N5Esfahan University of Medical Sciences66
Recruiting
Phase 3
The effect of melatonin in Ulcerative colitislcerative colitis.Ulcerative colitisIRCT20121021011192N9Shahid Beheshti University of Medical Sciences40
Not yet recruiting
Phase 3
The effect of melatonin on sleep quality in patients with mild traumatic brain injurymild traumatic brain injury.ConcussionS06.0XIRCT20220504054738N1Kashan University of Medical Sciences60