Is There a Microbiome Associated With Poor Growth in Preterm Infants?

Active, not recruiting

Brief Summary: This study evaluates the relationship between growth and stool microbiota in premature infants.

Detailed Description: Preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (NICU). While some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. Emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. We hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. This may ultimately represent a therapeutic target to improve the growth of preterm infants in the NICU. This study aims to describe the differences in microbiome which may vary with growth pattern.

Recruitment & Eligibility

Inclusion Criteria

All infants less than 28 weeks gestation who are admitted to the Parkland Hospital NICU.

Exclusion Criteria

Infants >27 weeks gestation. Infants with major congenital anomalies which may alter growth patterns.

Arm && Interventions

Group	Intervention	Description
Slow Growth	Caloric Requirement	Require more than 110 kcal/kg/day to maintain growth curve

Primary Outcome Measures

Name	Time	Method
quantitative rT-PCR of stool microbiome	8-10 weeks depending on length of stay in NICU	alpha diversity of bacterial groups in normal growth vs. poor growth

Secondary Outcome Measures

Name	Time	Method

Locations (1): Parkland Hopsital and Health System
🇺🇸
Dallas, Texas, United States

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