Is There a Microbiome Associated With Poor Growth in Preterm Infants?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Growth Disorders
- Sponsor
- University of Texas Southwestern Medical Center
- Enrollment
- 118
- Locations
- 1
- Primary Endpoint
- quantitative rT-PCR of stool microbiome
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
This study evaluates the relationship between growth and stool microbiota in premature infants.
Detailed Description
Preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (NICU). While some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. Emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. We hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. This may ultimately represent a therapeutic target to improve the growth of preterm infants in the NICU. This study aims to describe the differences in microbiome which may vary with growth pattern.
Investigators
Katherine Anne Stumpf
Assistant Professor of Pediatrics
University of Texas Southwestern Medical Center
Eligibility Criteria
Inclusion Criteria
- •All infants less than 28 weeks gestation who are admitted to the Parkland Hospital NICU.
Exclusion Criteria
- •Infants \>27 weeks gestation. Infants with major congenital anomalies which may alter growth patterns.
Outcomes
Primary Outcomes
quantitative rT-PCR of stool microbiome
Time Frame: 8-10 weeks depending on length of stay in NICU
alpha diversity of bacterial groups in normal growth vs. poor growth