NCT01881802UnknownNot Applicable
Study of Opioid Immunosuppressive Effects
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University0 sites50 target enrollmentStarted: March 2013Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 50
- Primary Endpoint
- real-time quantitative polymerase chain reaction
Study Overview
Brief Summary
This trial aims to investigate the effects of opioid-inducing immune suppression on opioid drug abused patients. The methods of the investigators research mainly includes the expression of morphine-related miRNAs in peripheral blood mononuclear cells and cytokine in plasma.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •subjects were excluded if they had a chronic systemic illness (cardiac, renal, pulmonary, hepatic, endocrine, metabolic, or autoimmune disorders) or
- •a major psychiatric disorder or
- •if they were abusing substances other than heroin (as determined by urine drug test result). For women, pregnancy was also a reason for exclusion.
Exclusion Criteria
- •Control subjects with no history of drug or alcohol abuse were also excluded if they had
- •major medical or psychiatric disorders
Outcomes
Primary Outcomes
real-time quantitative polymerase chain reaction
Time Frame: up to 2 months
Secondary Outcomes
- enzyme-linked immuno sorbent assay(up to 2 months)
Investigators
Xiaohong Long
doctoral candidate
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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