Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hookworm Infection
- Sponsor
- Brugmann University Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Amount and phenotype of Treg
- Last Updated
- 5 years ago
Overview
Brief Summary
The main objective of this study is to characterize the regulatory immune response induced by hookworm in an infected Vietnamese rural population from the periphery of HCM, evolution after infection treatment and during potential naturally reinfection.
Detailed Description
Population: 20 healthy adults (18-65 years) infected and non infected by Hookworm will be recruited and treated according to Good Clinical Practice recommendations. Allergy will be excluded by skin prick tests. Amount and phenotype of Treg will be explored at several time points. Subsequent culture with environmental antigen will be performed on cryopreserved cells.
Investigators
Olivier Michel
Head of clinic
Brugmann University Hospital
Eligibility Criteria
Inclusion Criteria
- •18-65 years old adults in good health status
- •To live in rural regions at risk of soil transmitted helminthes
- •Hookworm infection (infected group)
- •Uninfected by Hookworms (control group)
Exclusion Criteria
- •Pregnant woman
- •Positive allergic history
- •Auto-immune and/or HIV disease
- •Antihelminthics drug in the last 6 months and other current parasitic infection
Outcomes
Primary Outcomes
Amount and phenotype of Treg
Time Frame: 0-12 weeks
Four colors flow cytometry Treg measurements and phenotyping (FACSCantoII).