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Behavioral Exposure for Introceptive Tolerance RCT

Phase 2
Recruiting
Conditions
Anxiety
Cardiac Rehabilitation
Exercise Sensitivity
Introceptive Exposure
Interventions
Behavioral: Behavioral Exposure For Introceptive Tolerance
Behavioral: Health Education Control
Registration Number
NCT05398276
Lead Sponsor
Rutgers, The State University of New Jersey
Brief Summary

Behavioral Exposure for Interoceptive Tolerance (BE-FIT) is a mechanism-informed behavioral intervention to target exercise anxiety. The three primary components of BE-FIT include: (1) exposure to feared bodily sensations and exercise; (2) prevention of safety behavior use before/during/after exercise, and (3) use of a wrist-worn activity monitor for physical activity (PA) feedback and activity goal setting. Evidence from the investigators' Stage I trial indicated that BE-FIT is feasible, acceptable, and safe and produced reductions in exercise anxiety and increased exercise outcomes (short-term moderate-to-vigorous intensity physical activity and steps/day). The investigators' present aim is to conduct a Stage II randomized-controlled trial to further evaluate the efficacy of BE-FIT in decreasing exercise anxiety in cardiac rehabilitation (CR) patients and examine whether changes in this target yield successive changes in exercise adherence outcomes.

Detailed Description

This study is a Stage II randomized-controlled trial of a novel behavioral intervention, titled Behavioral Exposure for Interoceptive Tolerance (BE-FIT), to evaluate (1) its efficacy in improving exercise adherence in CR and (2) its mechanisms of change in individuals 40 years of age and older. One hundred and forty-six patients enrolled in Robert Wood Johnson University Hospital (RWJ) cardiac rehabilitation (CR) program who have elevated exercise anxiety, as indicated by endorsement of much to very much concern about at least 3 items on the Exercise Sensitivity Questionnaire (ESQ; Farris et al., 2020) and meet other eligibility criteria will be randomly assigned to either receive BE-FIT, a tailored intervention specifically for CR patients with high levels of exercise anxiety (n=73), or the health education condition (HEC; n=73), which are matched for contact time. Eligible participants will be stratified based on their risk profile (determined by their electronic health record), age, sex, and ESQ score. These stratification variables were selected because they are associated with anxiety and fitness levels which could impact physical activity (PA) outcomes. Both conditions will be administered by trained doctoral-level students enrolled at Rutgers University and will be supervised throughout the course of the study by Dr. Farris and other listed co-investigators.

The BE-FIT intervention is a cognitive-behavioral intervention and is designed to target exercise anxiety. The three main components of BE-FIT include: 1) exposure to feared bodily sensations and exercise, 2) prevention of safety behavior use before/during/after exercise, and 3) use of a wrist-worn activity monitor (Fitbit) for PA feedback and activity goal setting. The alternative type of intervention is the Health Education Control (HEC), which is a time-matched control intervention that will be delivered on the same delivery schedule as BE-FIT. The doctoral-level clinicians who will be delivering HEC will be exclusively trained in order to avoid contamination with the BE-FIT intervention. In this control arm, participants will be provided educational information about health topics relevant to healthy aging delivered through PowerPoint lectures and handouts and use a Fitbit for PA monitoring. The HEC protocol has been used in prior studies conducted by Dr. Abrantes (co-investigator).

The overall duration of the study is 24 weeks, or approximately 6 months. Subjects will be involved in 6 individual sessions delivered twice weekly during the initial weeks of outpatient CR. Sessions occur for 45 minutes either immediately before or after regularly scheduled CR sessions. Five independent assessments are conducted at baseline, EOT, and three follow-ups (Weeks 12, 18, 24). Data collection will occur at each visit, with baseline data collected at the initial visit.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
146
Inclusion Criteria
  1. ≥ 40 years of age
  2. Elevated exercise anxiety (score of ≥ 30 on ESQ-18)
  3. Low active (< 90 min self-reported moderate-to-vigorous intensity physical activity/day in past three months)
  4. Medically approved cardiac rehabilitation
  5. English proficiency
Exclusion Criteria
  1. Evidence of cognitive impairment (≤ 23 on Montreal Cognitive Assessment; MoCA)
  2. Severe disabling chronic medical and/or psychiatric comorbidities determined on a case-by-case basis that prevents safe or adequate participation
  3. Expectation that patient will not live through study periods

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Behavioral Exposure For Introceptive ToleranceBehavioral Exposure For Introceptive ToleranceThe BE-FIT intervention is a cognitive-behavioral intervention and is designed to target exercise anxiety. The three main components of BE-FIT include: 1) exposure to feared bodily sensations and exercise, 2) prevention of safety behavior use before/during/after exercise, and 3) use of a wrist-worn activity monitor (Fitbit) for PA feedback and activity goal setting.
Health Education ControlHealth Education ControlHEC is a time-matched control intervention that will be delivered on the same delivery schedule as BE-FIT. In this arm, participants will be provided educational information about health topics relevant to healthy aging delivered through PowerPoint lectures and handouts and use a Fitbit for PA monitoring.
Primary Outcome Measures
NameTimeMethod
Overall minutes of exercise24 weeks

Objectively measured exercise (moderate-to-vigorous intensity physical activity mins/day) on both CR and non-CR days.

Secondary Outcome Measures
NameTimeMethod
Objectively measured Lifestyle PA (steps/day).24 weeks
Percent of prescribed cardiac rehabilitation attended.24 weeks

Trial Locations

Locations (2)

RWJ Cardiac Rehab at East Brunswick

🇺🇸

East Brunswick, New Jersey, United States

Rutgers Emotion, Health and Behavior Laboratory Department of Psychology

🇺🇸

New Brunswick, New Jersey, United States

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