The Effect and Mechanism of Electroacupuncture on Acute Chemotherapy-induced Nausea and Vomiting
Not Applicable
- Conditions
- Lung Neoplasms
- Interventions
- Device: acupuncture (Huatuo)
- Registration Number
- NCT02469493
- Lead Sponsor
- Xidian University
- Brief Summary
The purpose of this study is to compare the preventive effect of electroacupuncture and sham acupuncture on acute chemotherapy-induced nausea and vomiting and then investigate its potential mechanism by using functional Magnetic Resonance Imaging (fMRI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
- First diagnosed stage Ⅲ-Ⅳ lung cancer patients on cisplatin chemotherapy;
- Right-handed and aged 18 to 75 years;
- Karnosky performance status (KPS) ≥ 70;
- Life expectancy ≥ 6 months.
Exclusion Criteria
- Had brain metastases or other concurrent life-threatening diseases;
- Nausea and/or vomiting were present 24h before chemotherapy treatment;
- Suffered from or had a history of gastrointestinal diseases;
- Had a history of head trauma, serious neurological or psychiatric disorders;
- Participating in other clinical trials currently;
- Had any contraindication to exposure to a high magnetic field or receive acupuncture
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Acupuncture 1 acupuncture (Huatuo) In this group, patients separately received twice electroacupuncture at bilateral PC6 acupoint before and after Cisplatin administration on the first day of chemotherapy. Acupuncture 2 acupuncture (Huatuo) In this group, patients separately received twice electroacupuncture at bilateral PC6 and RN12 acupoints before and after Cisplatin administration on the first day of chemotherapy. Sham acupuncture acupuncture (Huatuo) In this group, patients separately received twice electroacupuncture at bilateral nonacupuncture point (S1 located at lateral of flexor carpi radialis, 2 cun above the wrist. S2 located at 3 cun right side of RN12) before and after Cisplatin administration on the first day of chemotherapy.
- Primary Outcome Measures
Name Time Method The scores of Rhodes Index of Nausea, Vomiting and Retching. 24 hours
- Secondary Outcome Measures
Name Time Method Content of 5-hiaa in urine 12 hours Heart Rate Variability 1 hour Tachygastria percentage 1 hour Dosage of antiemetic drugs 24 hours
Trial Locations
- Locations (1)
Xijing Hospital
🇨🇳Xi'an, Shaanxi, China