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临床试验/CTRI/2025/03/083416
CTRI/2025/03/083416尚未招募不适用

Comparative evaluation of effect of herbal based mouthwash in gingivitis patient a randomized controlled trial

self1 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2025年7月6日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
52
试验地点
1
主要终点
gingival index, plaque index

研究概览

简要总结

Statement of problemThe peel of Citrus reticulata is widely used for various health benefits, including treating skin and stomach ailments, cancer, and as a diuretic, carminative, and immune-enhancing agent. It is also effective in preventing and treating vitamin deficiencies, colds, flu, scurvy, and combating bacterial and viral infections. Similarly, Jamun, also known as Syzygium cumini (family Myrtaceae), has significant medicinal value, particularly its seeds. While single-herbbased mouthwashes are available on the market, there is a lack of literature on polyherbal mouthwashes for the treatment of gingivitis. This paper proposes the effectiveness of a polyherbal mouthwash containing Syzygium cumini seed and orange peel for gingivitis patients. TreatmentNatural and herbal mouthwashes are becoming increasingly popular due to their numerous benefits over chemical agents. This rise in popularity can be attributed to their widespread availability, minimal or no side effects, moderate efficacy, and lower cost compared to chemical mouthwashes. The herbal extract proposed in this paper combines Syzygium cumini seed and orange peel. Orange, a tangy and juicy fruit from the Rutaceae family, is scientifically known as Citrus reticulata. Jamun, also called Syzygium cumini, belongs to the Myrtaceae family. Both fruits exhibit various beneficial effects, including antimicrobial, antioxidant, anticancer, and antitumor properties. Studies on the antimicrobial effects of herbal extracts have shown that they are effective against anaerobic periodontopathogens. Specifically, the minimal inhibitory concentration (MIC) of orange peel and Syzygium cumini seed extract was determined, demonstrating its effectiveness against three periodontopathogens: Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), and Porphyromonas gingivalis (Pg). Therefore, this extract can be effectively used in patients with chronic periodontitis. Sequential Procedure- ï‚· Diagnosis of the condition. ï‚· Detailed assessment of gingival status, including gingival index, plaque index, and bleeding on probing. ï‚· Sterilization of instruments. ï‚· Sequential arrangement of instruments. ï‚· Preparation with the operator’s gown and patient’s drape. ï‚· Perform scaling and root planing (non-surgical periodontal therapy, NSPT). ï‚· Prescribe and provide instructions for the use of mouthwash. ï‚· Demonstrate the correct brushing technique. ï‚· Re-evaluate the patient after 21 days, including: o Assessment of the patient’s oral hygiene status. o Re-evaluation of plaque and gingival indices.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 45.00 Year(s)(—)
性别
All

入选标准

  • Minimum of 20 teeth should be present in the dentition, no visible signs of untreated caries.
  • Patient diagnosed with mild to moderate type of gingivitis.
  • Patient with bleeding on probing present, clinically.
  • Patient who had not received any periodontal therapy for the past 6 months.
  • Patient willing to give the informed consent and willing to comply with the study will be included.

排除标准

  • Patients suffering with any known systemic disease.
  • Patients having periodontitis
  • Patients having malocclusion.

结局指标

主要结局

gingival index, plaque index

时间窗: baseline , 4 weeks

次要结局

  • papillary bleeding index(baseline , 4 weeks)

研究者

发起方
self
申办方类型
Research institution
责任方
Principal Investigator
主要研究者

Preshita Barai

Ranjeet deshmukh dental college and research centre

研究点 (1)

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