Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis (DHBN-FN) Mono- or Multi-microbial Streptococcus Beta-haemolytic: Study of Carriage in Patients and Their Entourage
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Rate of beta-hemolytic streptococcus in patients with DHBN-FN
研究概览
简要总结
The aim of the study is to evaluate streptococcal carriage by swab, pharyngeal, anal and perineal in patients with DHBN-FN, in the entourage living under the same roof as well as patients with erysipelas
The main hypothesis is the major role of chronic porting of patients and entourage in DHBN-FN to SBH.
Indeed, the chronic pharyngeal / anal / perineal carriage could be a gateway following a transient bacteremia for a DHBN-FN.
The transmission of germs from the surrounding to the patient plays a major role:
At the gateway level in the case of exogenous DHBN-FN At the origin of chronic carriage in the case of endogenous DHBN-FN Transmission of germs from the patient to the surrounding area also plays an important role in increasing the risk of invasive SBH infections in the surrounding area.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Major patient hospitalized for a DHBN-FN or erysipelas (clinical diagnosis determined at the entrance).
- •Signed informed consent.
- •Case contact
- •person of major age living under the same roof as a patient who has had a DHBN-FN.
- •Signed informed consent
排除标准
- •Minor patient
- •Immunosuppressed patient: active hematology, poorly controlled HIV, neutropenia (PNN <1000 / mm3).
- •Patient under guardianship or curatorship
- •Patient deprived of liberty by judicial or administrative decision
- •Patient not affiliated to a social security scheme and not a beneficiary of such a scheme
- •Case contact
- •Minor person
- •Person under tutorship or curatorship
- •Person deprived of liberty by judicial or administrative decision
- •Person not affiliated with a social security
研究组 & 干预措施
DHBN-FN arm
Recruitment is planned in traditional hospitalization for DHBN-FN patients. Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN at the end of hospitalization and 1 month after discharge from hospital during the reassessment consultation. Swabs made by the dermatologist.
The carriage of streptococcus in patients living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal swab, anal and perineal. If the family accepts, the carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index
干预措施: DHBN-FN arm (Other)
Control arm (Erysipelas)
Recruitment is planned in traditional hospitalization for patients with erysipelas.
The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0 (admission).
干预措施: Control arm (Erysipelas) (Other)
结局指标
主要结局
Rate of beta-hemolytic streptococcus in patients with DHBN-FN
时间窗: Day 30
Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture
Rate of beta-hemolytic streptococcus in patients with DHBN-FN
时间窗: Day 0
Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture
Rate of beta-hemolytic streptococcus in patients with DHBN-FN
时间窗: 1 month after hospitalization discharge
Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture
次要结局
- Prevalence of SBH carriage at the time of diagnosis(Day 0, Day 10)
- Sites of SBH carriage at the time of diagnosis(Day 0, Day 10)
- Rate of beta-hemolytic streptococcus in patients with erysipelas(Day 0)
- Rate of beta-hemolytic streptococcus in patients living under the same roof as patients with DHBN-FN(Up to 10 Days)
- Main factors of streptococcal virulence(Day 0, Day 10)