Efficacy of Methotrexate on Chronic Chondrocalcinosis

• Conditions: Chronic Chondrocalcinosis

• Registration Number: EUCTR2007-003479-37-IE
• Lead Sponsor: niversity Hospital of Geneva

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10-11
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients recruited to participate in this trial will satisfy the following criteria;

Patients must have a definite diagnosis of Crystal Pyrophosphate Dihydrate (CPPD) disease using the Mc Carty diagnostic criteria.

Patients who have had an unsatisfactory response to at least one non steroidal anti-inflammatory medication (NSAID) or low dose steroid.

Contraindications to the use of NSAID and glucocorticoid medication

Recurrent mono or oligoarthritis (pseudogout) (experiencing at least three flares in 6 months) or persistent polyarthritis
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Patients will be excluded from study participation for the following reasons;

Any contraindication to Methotrexate (hepatic failure, alcohol consumption, severe renal failure, haematological diseases, or acute infection

A diagnosis of Rheumatoid Arthritis, Connective Tissue Disease or Gout.

Literacy difficulties which will compromise their ability to fill out the study questionnaires

Patients whose ability to give informed consent may be compromised

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified