Construction of Gynecological Tumor Organoids

Not yet recruiting

• Conditions: Organoid; Gynecologic Cancer
• Interventions: Other: construction of organoids from gynecological tumor

• Registration Number: NCT06155370
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.

Detailed Description

Explore the construction and maintenance of a large-scale queue of gynecological tumor organoids. Beijing Daxiang Technology Co., Ltd. provides corresponding technical support and chip design. Gynecological oncology center provides tumor samples, clinical information, and pathological support, and biological sample library provides technical support, storage space, and quality management.

Study Timeline

• Status Verified: 2023-11
• Study First Submitted: 2023-11-23
• Study First Submitted QC: 2023-11-23
• Last Update Submitted: 2023-11-23
• Study Start: 2023-12-01
• Study First Posted: 2023-12-04
• Last Update Posted: 2023-12-04
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

1. Age of 18 or older, an informed consent form is provided;
2. The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible;
3. Having relevant requirements for sample library storage;
4. Surgical treatment at Peking Union Medical College Hospital.

Exclusion Criteria

1. Unable to meet all inclusion criteria;
2. The research team considers any situations or considerations that may hinder normal pathological assessment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cohort of vulva cancer organoids	construction of organoids from gynecological tumor	organoids derived from vulva cancer
cohort of gestational trophoblastic tumor organoids	construction of organoids from gynecological tumor	organoids derived from gestational trophoblastic tumor
cohort of ovarian cancer organoids	construction of organoids from gynecological tumor	organoids derived from ovarian cancer
cohort of cervical cancer organoids	construction of organoids from gynecological tumor	organoids derived from cervical cancer
cohort of endometrial cancer organoids	construction of organoids from gynecological tumor	organoids derived from endometrial cancer
cohort of vaginal cancer organoids	construction of organoids from gynecological tumor	organoids derived from vaginal cancer

Primary Outcome Measures

Name	Time	Method
Construction of BioBank	one year	BioBank including organoids banks, tissue banks, PDX banks, immune cell banks, and primary banks from other tissue sources

Secondary Outcome Measures

Name	Time	Method
Exploring the molecular mechanism based on organoids banks	one year	Exploring the molecular mechanism of gynecological tumor pathogenesis based on organoid banks
Drug sensitivity detection based on organoids banks	one year	Exploring drug sensitivity detection in gynecological tumors based on organoid libraries