Validity and reliability testing of the Timed-Up and Go Test in patients with haemophilia

Recruiting

Conditions: D66
D67
Hereditary factor VIII deficiency
Hereditary factor IX deficiency

Registration Number: DRKS00034103

Lead Sponsor: Bergische Universität Wuppertal, Lehrstuhl für Sportmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Male

Target Recruitment: 40

Inclusion Criteria

Adult diagnosed with moderate and severe haemophilia A or B.
- age = 18 years

Exclusion Criteria

- Suffering from other bleeding diseases outside of haemophilia
- any invasive joint therapies (e.g., radiosynoviorthesis) or surgeries (e.g., TEP or arthrodesis) up to 6 months before the examination date
- acute analgesic drug intake outside of the patient’s regular treatment regime 12 hours before the examination.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the convergent construct validity: The validity of the TUG is assessed by correlating the results of the TUG (time in seconds) with those of the already validated Haemophilia Joint Health Score (a test to assess joint health; score range 0-124), and with an established objective clinical test measuring the same construct, namely the Short Physical Performance Battery (SPPB), which includes the 5-time sit to stand test and the 4-meter walk test; score range 0-12). Additionally, the results are correlated with subjective measures of physical function and mobility, including the Haemophilia Activity List (HAL; score range 0-100), the Haemophilia and Exercise Project-Test-Questionnaire (HEP-Test-Q; score range 0-100), and subjective weekly physical activity time (time in minutes per week).

Secondary Outcome Measures

Name	Time	Method
- Test-Retest Reliability<br>- Inter-Rater Reliability<br>- Discriminant (known groups) construct validity<br>- Standard error of measurement<br>- Minimum detectable change