The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Rate of Orthodontic Canine Retraction
研究概览
简要总结
This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 17 Years 至 29 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy individuals aged 17-29 years (mean age 24 ± 6 years)
- •Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions
- •Full permanent dentition
- •Good oral hygiene
- •Non-smokers
- •Not taking medications affecting bone metabolism (e.g., bisphosphonates)
排除标准
- •Pregnancy or breastfeeding
- •Contraindications to platelet therapies (e.g., platelet dysfunction)
- •Severe malocclusion unsuitable for fixed appliances
- •Dental anomalies (size/shape)
- •Systemic syndromes
研究组 & 干预措施
PRP vs Control (Split-Mouth)
Split-mouth group in which one side received platelet-rich plasma (PRP) injection and the contralateral side served as a control without injection during orthodontic canine retraction.
干预措施: Platelet-Rich Plasma (PRP) (Biological)
PRF vs Control (Split-Mouth)
Split-mouth group in which one side received platelet-rich fibrin (PRF) injection and the contralateral side served as a control without injection during orthodontic canine retraction.
干预措施: Platelet-Rich Fibrin (PRF) (Biological)
结局指标
主要结局
Rate of Orthodontic Canine Retraction
时间窗: From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.
The amount of orthodontic canine movement measured in millimeters.
次要结局
未报告次要终点
研究者
Yusra Ali Al Shawri
Principal Investigator
Sana'a University