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临床试验/CTRI/2022/04/041751
CTRI/2022/04/041751已完成不适用

MICRO PUCH GRAFTING (MICRO PG) BY USING MOTORIZED POWER PUNCHES AS A TISSUE EXTRACTOR 0.8 MM IN STABLE AND LIP VITILIGO: A NOVEL APPROACH IN STABLE VITILIGO

NA1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2022年4月14日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
NA
入组人数
10
试验地点
1
主要终点
To know the efficacy of repigmentation in stable lip Vitiligo by motorized motorized micro punch grafting technique

研究概览

简要总结

Vitiligois a common disorder of pigmentation.1 Pathogenetically, vitiligo represents a complex reactionpattern involving multiple etiologic factors, some of them necessarily workingin concert. On-going research is focussing on a better understanding ofpathogenesis and thus searching for better treatment modalities. Treatmentis classified into medical, light-based, surgical, camouflage, anddepigmentation therapy2.

Surgicaltreatment is generally considered when medical/light-based treatment has failedand includes tissue transfer (e.g., punch grafting, partial split-thicknessgrafting, and suction blister grafting) and cellular transfer, which is furtherdivided into cultured and non-cultured techniques.3-5  The basic principle of surgical treatment isto transfer the melanocytes from normal skin to-vitiliginous skin. Non-culturedepidermal cell suspension (NCES) is considered the standard and most effectivesurgical treatment for stable vitiligo and, it along with suction blistergrafting (SBG), has a better outcome than other surgical methods.6

Autologous mini punch grafting is the easiest,effective, and less expensive method of vitiligo surgery. It is indicated inalmost all sites especially in acral vitiligo involving palms, fingers, nipples,and lips.7

Thetechnique of Mini punch grafting (MPG)  hasundergone many modifications over the years to reduce the requirement forequipment and to save time. The timeconsumed in MPG using punches of less than 1.5 mm is more when compared withpunch grafting with 2-3 mm punches, moreover the number of grafts required isalso more with a decrease in punch sizes. With the advent of motorized powerpunches the procedure can be done with more ease in lesser time to harvest moremini grafts (<1.5 mm) in a single session.7

A newer technique of Motorized 0.8-mm micro punchgrafting for refractory vitiligo from a retrospective study of 230 casesconcluded that refractory vitiligowith short procedure times had an excellent outcome. This technique could be arapid and convenient surgical option with acceptable adverse events and ispromising for treating refractory vitiligo on an outpatient basis, particularlyin patients who are unlikely to tolerate prolonged surgery.8

Wealso want to know the efficacy of the same by doing it in the exclusive lipvitiligo and to look at the adverse effects of the 0.8mm micro punchgrafting.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Not Applicable

入排标准

年龄范围
15.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Age > 15 years
  • The vitiligo stability of at least 12 months
  • Patient not responding to medical management.

排除标准

  • Unstable vitiligo
  • Tendency for hypertrophic and keloid scars
  • History of bleeding diathesis
  • Pregnancy and lactation
  • Active infection in Donor or recipient site.

结局指标

主要结局

To know the efficacy of repigmentation in stable lip Vitiligo by motorized motorized micro punch grafting technique

时间窗: After 3 months

次要结局

  • To know the Side effect profile of the motorized MPG technique(After 3 months)

研究者

发起方
NA
申办方类型
Other [nil]

研究点 (1)

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