Evaluation of Fractional CO2 and Non Ablative Long Pulsed Nd YAG Lasers Alone and in Combination in Treatment of Keloids
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 30
- Primary Endpoint
- comparison between different laser modalities in treatment of keloids clinically
Study Overview
Brief Summary
clinical comparative study comparing the effectiveness of fractional CO2, long pulsed Nd YAG and their combination in collagen remodeling in keloid clinically, biochemically and histopathologically
Detailed Description
Patients The study included 30 Egyptian patients with keloid scar recruited from the Out Patient Clinic, Dermatology Department, Cairo University.
Methodology
Patients:
-
Thirty patients with keloid scar(s) were included in the study
-
Every patient was subjected to the following:
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with keloid scars of at least 6 months duration.
- •No limitations regarding sex of the patients.
- •Patients with three or more lesions 2 to 3 cm apart or patients having a large sized lesion.
Exclusion Criteria
- •Patients who had received any form of treatment during the last four weeks prior to treatment such as intralesional steroids or a laser procedure during the last six months.
- •Patients with active skin infections e.g. herpes or autoimmune disease.
- •Patients with previous history of adverse outcome related to laser therapy.
- •Recent use of Isotretinoin (within 6 months prior to the procedure).
- •Patients with known allergies to lidocaine.
- •Smoking, pregnancy
- •Patients with unrealistic expectations
Arms & Interventions
fractional CO2 laser 10,600nm
fractional CO2 laser 10,600nm one session every month for 4 months
Intervention: fractional CO2 laser 10,600nm (Device)
Nd YAG laser 1064nm
Nd YAG laser 1064nm
Intervention: Nd YAG laser1064 nm (Device)
combined two laser types
combined fractional CO2 laser 10,600nm and Nd YAG laser 1064nm lasers treatment to keloid
Intervention: fractional CO2 laser 10,600nm (Device)
combined two laser types
combined fractional CO2 laser 10,600nm and Nd YAG laser 1064nm lasers treatment to keloid
Intervention: Nd YAG laser1064 nm (Device)
Outcomes
Primary Outcomes
comparison between different laser modalities in treatment of keloids clinically
Time Frame: 5 months
assessed by Patient and Observer Scar assessment Scale
comparison between different laser modalities in treatment of keloids morphometrically
Time Frame: 5 months
assessed by Quantitative morphometric analysis using Leica Qwin 500 Image Analyzer (LEICA Imaging Systems Ltd, Cambridge, England) measuring area percent of collagen and elastin fibers in micrometer squared
comparison between different laser modalities in treatment of keloids biochemically
Time Frame: 5 months
assessed by level of transforming growth factor beta 1 and 3 using Human TGF-B ELISA kit provided by ID labs Biotechnology London, ON, Canada.measurement unit is nano gram per gram tissue
Secondary Outcomes
No secondary outcomes reported
Investigators
Ahmed Foad Mohamed
specialist of dermatology.students hospital. Cairo university
Cairo University