Effects of Melatonin on incidence of delirium in the critically ill patients in ICU Maharaj Nakorn Chiang Mai hospital, A randomized control trial
Phase 4
Active, not recruiting
- Conditions
- Patient admitted in ICU Maharaj Nakorn Chiang Mai hospital
- Registration Number
- TCTR20180504002
- Lead Sponsor
- Faculty of medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- age over 18 years old
- admit in ICU with acute respiratory failure require mechanical ventilator
- GCS > 10
- can receive enteral feeding
Exclusion Criteria
- Have delirium at the time of enrolment
- prior treatment of sleep disturbance and delirium or use continuous intravenous sedative for deep sedative effects or muscle paralysis drugs
- pregnant and breast feeding
- history of neurological disease, convulsion, psychiatric
- conditions likely to affect the enteral absorption such as intestinal obstruction, ileus, gastroparesis
- expect length of stag < 48 hr
- known allergic to melatonin
- re-admitted to ICU after randomized to study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of delirium occurs in patient admitted in ICU At the time of the ICU discharge Occurrence of delirium will be recorded every day during ICU stay using CAM-IC
- Secondary Outcome Measures
Name Time Method Mechanical ventilator (MV) day Date of taking off MV Duration of MV dependent