Identification of Genotype-related Molecular Targets in the Vitamin D Pathway for Personalized Pharmacological Treatments of the Spinal Disc Diseases
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Phenotype and genotype characterization
Study Overview
Brief Summary
The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with spinal disc diseases
- •males and females
- •18≤age ≤ 70 years old
- •Italian white
- •patients with spinal disc diseases that will be surgically treated
- •Exclusion criteria:
- •age < 18 or > 70 years old
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Phenotype and genotype characterization
Time Frame: 1 year
To evaluate structural alterations of the intervertebral disc and of the cartilage endplate in patients with spinal disc diseases related to functional FokI polymorphism in the vitamin D receptor (VDR) gene.
Secondary Outcomes
- Disc cell functional response genotype-based(2 years)