ChiCTR2300069642Not yet recruiting诊断试验新技术临床试验
经颅多普勒超声发泡试验检测右向左分流的临床研究
本人既往课题经费结余（2017 年四川省医学会科研青年创新课题 Q17061）1 site in 1 countryStarted: April 1, 2023Last updated:
Trial Snapshot
- Phase
- 诊断试验新技术临床试验
- Status
- Not yet recruiting
- Sponsor
- Locations
- 1
- Primary Endpoint
- 微栓子个数
Study Overview
Brief Summary
以经食道超声心动图 / 经胸超声心动图声学造影及胸部 CTA 为金标准，初步探索 c-TCD 的诊断准确性,并优化 c-TCD 的操作流程。
Study Design
- Study Type
- 诊断试验
- Primary Purpose
- 诊断试验诊断准确性
- Masking
- 无
Eligibility Criteria
- Ages
- 16 to 55 (—)
- Sex
- All
Inclusion Criteria
- •临床疑似右向左分流的患者：
- •存在隐源性脑卒中或高风险 TIA 的证据；
- •其它临床高度怀疑存在右向左分流的情况；
- •顺利完成经食道超声心动图（或经胸超声心动图声学造影）评估右向左反流的检查及胸部 CT 血管成像评估肺动静脉瘘的检查。
Exclusion Criteria
- •颈动脉超声或 CTA/MRA/DSA 明确存在动脉粥样硬化性狭窄或动脉夹层、动脉炎等导致脑卒中的病变；
- •存在室间隔缺损的患者；
- •存在严重多脏器功能衰竭者；
- •存在智力障碍、听力严重障碍患者；
- •各种原因不能接受静脉注射激活生理盐水的患者。
Outcomes
Primary Outcomes
微栓子个数
Time Frame: 经静脉注入激活生理盐水后 25s 内
阳性检出率
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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