Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 主要终点
- Skeletal Muscle Hypertrophy (lean body mass in Kilograms)
研究概览
简要总结
Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Physical active
- •Non-smokers
- •Non-asthmatics
- •No chronic diseases
- •Informed consent
排除标准
- •Allergy towards study drug
研究组 & 干预措施
Experimental
Beta2-adrenergic stimulation with salbutamol and resistance training for 10 weeks
干预措施: Resistance training (Other)
Experimental
Beta2-adrenergic stimulation with salbutamol and resistance training for 10 weeks
干预措施: Salbutamol (Drug)
Control
Placebo and resistance training for 10 weeks
干预措施: Placebo (Drug)
Control
Placebo and resistance training for 10 weeks
干预措施: Resistance training (Other)
结局指标
主要结局
Skeletal Muscle Hypertrophy (lean body mass in Kilograms)
时间窗: 2 days
Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)
次要结局
- Left Ventricular Hypertrophy (mass in grams)(1 day)
研究者
Morten Nielsen
Post.Doc
University of Copenhagen