Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men
Overview
- Phase
- Not Applicable
- Intervention
- Resistance training
- Conditions
- Muscle Hypertrophy in Healthy Young Men
- Sponsor
- University of Copenhagen
- Enrollment
- 42
- Primary Endpoint
- Skeletal Muscle Hypertrophy (lean body mass in Kilograms)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.
Investigators
Morten Nielsen
Post.Doc
University of Copenhagen
Eligibility Criteria
Inclusion Criteria
- •Physical active
- •Non-smokers
- •Non-asthmatics
- •No chronic diseases
- •Informed consent
Exclusion Criteria
- •Allergy towards study drug
Arms & Interventions
Experimental
Beta2-adrenergic stimulation with salbutamol and resistance training for 10 weeks
Intervention: Resistance training
Experimental
Beta2-adrenergic stimulation with salbutamol and resistance training for 10 weeks
Intervention: Salbutamol
Control
Placebo and resistance training for 10 weeks
Intervention: Placebo
Control
Placebo and resistance training for 10 weeks
Intervention: Resistance training
Outcomes
Primary Outcomes
Skeletal Muscle Hypertrophy (lean body mass in Kilograms)
Time Frame: 2 days
Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)
Secondary Outcomes
- Left Ventricular Hypertrophy (mass in grams)(1 day)