Sugammadex Reversal of Neuromuscular Blockade and Postoperative Bleeding
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- activated partial thromboplastin tile in seconds
研究概览
简要总结
Sugammadex is new drug that is used for reversal of rocuronium induced muscle relaxation. benefits of reversal of neuromuscular blockade appears to be of great value in living donor liver transplant recipients. However, Few Clinical reports have investigated the anticoagulant effect of sugammadex. In this study, effects of sugammadex on bleeding profile of living donor liver transplantation will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all candidates for living donor liver transplantation
排除标准
- •massive intraoperative bleeding manifestations of early graft dysfunction
研究组 & 干预措施
Control
Reversal of neuromuscular blockade will be performed using classic drugs (neostigmine 80 mic/kg and atropine 40 mic/kg)
干预措施: Intravenous neostigmine and atropine (Drug)
Sugammadex group
Reversal of neuromuscular blockade will be performed using Sugammadex 2mg/kg
干预措施: Sugammadex intravenous (Drug)
结局指标
主要结局
activated partial thromboplastin tile in seconds
时间窗: 30 min
次要结局
- international normalized ratio in second(30 min)
研究者
AlRefaey Kandeel
lecturer of anesthesia
Mansoura University