Cognitive Rehabilitation of Blast-induced Traumatic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 77
- 试验地点
- 2
- 主要终点
- Cognitive functioning
研究概览
简要总结
The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).
详细描述
The most common impairments following blast-induced traumatic brain injury (bTBI) are cognitive deficits in the domain of executive functioning, learning and memory, and functional and psychosocial disabilities that are closely related to these cognitive deficits. There are no treatment protocols available to address the multiple cognitive impairments in bTBI, but cognitive rehabilitation has proven efficacious in the treatment of non-blast TBI. The cognitive training modules the investigators plan to evaluate have improved organization and memory function in patients with non-blast TBI, but it is unknown whether their efficacy exceeds that of programs that focus only on education and support. This study is a between group comparison of a cognitive rehabilitation treatment designed specifically to address the most common cognitive complaints in executive and memory function, and an active control group receiving educational intervention geared at personal management of TBI-related symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 50 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) active-duty personnel or Veterans exposed to blast
- •Meets criteria for mild TBI
- •loss of consciousness (LOC) of 30 min or less
- •Age: 21- 50
排除标准
- •Evidence of penetrating head injury
- •History of previous neurological diagnosis
- •History of previous psychotic disorder prior to the blast exposure
- •Hearing or vision impairment
研究组 & 干预措施
Arm 1
Cognitive intervention
干预措施: Cognitive Intervention (Behavioral)
Arm 2
Educational intervention
干预措施: Educational intervention (Behavioral)
结局指标
主要结局
Cognitive functioning
时间窗: Ten weeks
Scaled Score on the standardized neuropsychological testing
次要结局
- Daily functioning(Ten weeks)
