Correlation of Vestibulo-ocular reflex and Pre-frontal cortex connectivity with Motor skills and Functional performance in children with Cerebral palsy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 56
- Locations
- 1
Study Overview
Brief Summary
This observational cross- sectional study is carried out in children aged 5 to 12 years with cerebral palsy and typically developing children. The study includes two groups consisting of children with spastic diplegic and hemiplegic cerebral palsy n - 26 and age matched typically developing children n -26 who serve as the comparator group. The study is non- interventional, and no therapeutic or experimental procedures are provided to any participant.
Following informed consent from parents children meeting the inclusion criteria are enrolled in the study and undergo assessment at a single time point. Prefrontal cortex connectivity is assessed using electroencephalography during resting state recording. Vestibulo - ocular reflex function is assessed using electrooculography in combination with a gyroscope to record eye movements and head motion during controlled horizontal and vertical head movement tasks.
Motor skills are assessed using the Gross Motor Function Measure 66 and functional performance is assessed using the Pediatric Evaluation of Disability Inventory. Correlation analysis is performed between prefrontal cortex connectivity and motor skills and functional performance scales, and another correlation is made between vestibulo- ocular reflex function and motor skills and functional performance scales within each group. The correlation findings obtained from both groups are then compared. All assessments are non-invasive and completed in a single session.
It is hypothesized that vestibulo- ocular reflex function and prefrontal cortex connectivity are significantly correlated with motor skills and functional performance in children with cerebral palsy.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 5.00 Year(s) to 12.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Children aged 5 to 12 years with a confirmed diagnosis of Diplegic and Hemiplegic cerebral palsy by a pediatrician.
- •Level of Sitting Scale score greater than 4 indicating the child can sit with minimal support.
- •Children with Cerebral palsy who could understand the task to fix a picture on a wall.
- •Children with cerebral palsy classified within Gross Motor Function Classification System Levels I to III.
- •Written informed consent obtained from parents or legal guardians.
- •The guardian of the child must be able to read either Hindi or English to provide informed consent by signing the consent form.
Exclusion Criteria
- •Children diagnosed with ataxic or dyskinetic sub types of Cerebral palsy.
- •Severe spasticity or bone deformities that would hinder participation or task execution.
- •Children who are classified above the level III of Gross Motor Function Classification System are not included in the study Presence of frontal cortical lesions as these may directly affect prefrontal function.
- •Manual Ability Classification System levels IV handles a limited selection of easily managed objects in adapted situations and V does not handle objects and has severely limited ability to perform simple actions.
- •Arm weakness due to neurological conditions such as brachial plexus injuries.
Investigators
Denesa Nagpal
Amity Institute of Health Allied Sciences