Therapeutic efficacy surveillance of malaria treatment and drug resistance monitoring in Gia Lai and Phu Yen provinces of Central Vietnam

Australian Defence Force Malaria and Infectious Disease Institute0 sites210 target enrollmentAugust 17, 2021

Overview

No summary available.

Registry

who.int

Start Date

August 17, 2021

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

Australian Defence Force Malaria and Infectious Disease Institute

•People infected with uncomplicated mono\-infections of P. falciparum and uncomplicated mono\-infections of P. vivax;
•Malaria parasite density of P. falciparum (\= 500 to \< 100,000 parasites/µL);
•Malaria parasite density of P. vivax (\= 250 parasites/µL);
•Children (\=5 years and \=20 kg to \<18 years old) and adults (\=18 to \<60 years old) infected with P. falciparum, children (\=5 to \<18 years old) and adults (\=18 to \<60 years old) infected with P. vivax malaria;
•Gender: Males and females;
•Working or residing at the study commune;
•Able to provide information and capillary finger prick blood samples;
•Written informed consent given to participate in the study by the adult or in case of children up to \<18 years old (Assent form for children aged 12 to \<18 years old) with parent or guardian permission;
•Normal G6PD enzyme activity levels (\>70%) of the site median value for G6PD normals for participants to be treated with primaquine for the radical cure of P. vivax malaria.

•People not infected with malaria infections;
•Children (\<5 years old and \<20 kg)infected with P. falciparum and less than 5 years of age infected with P. vivax malaria;
•Unwilling to provide consent, information, and capillary finger prick blood sample;
•Inability to communicate well with the study staff (poor mental development or evidence of psychiatric disorder);
•People with P. vivax malaria who have G6PD deficient enzyme activity;
•Pregnant or lactating females;
•Any condition that in the judgment of the IMPE\-QN/MIPM doctor would make participation in the study unsafe for the potential participant.