Effects of OCTA-guided PDT in Acute CSC

Not Applicable

Completed

• Conditions: Central Serous Chorioretinopathy; Tomography, Optical Coherence
• Interventions: Procedure: ICGA-guided Photodynamic therapy; Procedure: OCTA-guided Photodynamic therapy

• Registration Number: NCT03497000
• Lead Sponsor: Peking University People's Hospital

Brief Summary

OCTA-guided PDT is as safe and effective as ICGA-guided PDT in the treatment of acute central serous chorioretinopathy. Or OCTA-guided PDT is more effective than ICGA-guided PDT in the treatment of acute central serous chorioretinopathy, safe as well.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-01
• Primary Completion: 2017-12-01
• Study Completion: 2018-03-27
• Study First Submitted: 2018-03-28
• Status Verified: 2018-04
• Study First Submitted QC: 2018-04-05
• Study First Posted: 2018-04-12
• Last Update Submitted: 2018-04-14
• Last Update Posted: 2018-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA
• Presence of SRF and/or serous pigment epithelial detachment on OCT
• Presence of abnormal dilated choroidal vasculature in ICGA

Exclusion Criteria

• Patients with other ocular conditions commonly associated with SRF, such as choroidal neovascularization, polypoidal choroidal vasculopathy (PCV), diabetic retinopathy, retinal vascular occlusion, Coat's disease
• Any disease that may affect the quality of imaging (quality of OCTA images < 6), such as cataract, high myopia or nystagmus
• History of ocular surgeries including retinal laser
• Pregnancy
• Any uncontrolled systemic disease
• Any condition rendering patients intolerable to image acquisition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ICGA group	ICGA-guided Photodynamic therapy	Patients in this group underwent normal ICGA-guided half dose photodynamic therapy.
OCTA group	OCTA-guided Photodynamic therapy	Patients in this group underwent OCTA-guided half-dose photodynamic therapy.

Primary Outcome Measures

Name	Time	Method
Number of patients with subretinal fluid resolution on OCT after PDT of two groups	3 months

Secondary Outcome Measures

Name	Time	Method
Number of patients with leakage point resolution on FFA after PDT of two groups	3 months
BCVA (best corrected visual acuity) at every follow-up of two groups	1 month, 3 months
Number of recurrent CSC after PDT of two groups	3 months

Trial Locations

Locations (1)

People's Hospital of Peking University; 🇨🇳 Beijing, Beijing, China