Pulmonary rehabilitation in COPD and interstitial lung diseases

Not Applicable

• Conditions: COPD, interstitial lung diseases with or without pulmonary hypertension; Respiratory

• Registration Number: ISRCTN13019180
• Lead Sponsor: ational Koranyi Institute for Pulmonology

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34662293/ (added 21/10/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36141823/ (added 29/09/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-01-16
• Last Update Posted: 20 February 2023
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

1. Patients with COPD or interstitial lung disease
2. Age between 30 and 80 years
3. Able to perform respiratory training and endurance training
4. Able to understand the meaning of the program
5. Without significant psychological disease, which has influence the outcome of the rehabilitation

Exclusion Criteria

1. Not able to perform the pulmonary rehabilitation program because of joint disease
1. Not able to perform the pulmonary rehabilitation program because of psychological disorder

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Lung function is measured using spirometry at end of rehabilitation and at 6 and 12 months<br> 2. Oxygen uptake is measured using the cardiopulmonary exercise test at the end of the rehabilitation and at 6 and 12 months<br> 3. Metabolism at the end of the rehabilitation is measured using the cardiopulmonary exercise test at the end of the rehabilitation and at 6 and 12 months<br> 4. Systemic inflammation is measured by routine laboratory methods for hsCRP, ELISA for cytokines, sputum and plasma concentration with HPLC at the end of rehabilitation, 6 and 12 months<br> 5. Oxidative stress is measured by enzyme immunoassay techniques at the end of rehabilitation, 6 and 12 months<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Chest kinematics is measured using thoracic circumference at the end of the rehabilitation and at 6 and 12 months<br> 2. Lung mechanics is measured using lung function at the end of the rehabilitation and at 6 and 12 months<br> 3. Peripheral and respiratory muscle function is measured using grip strength and peripheral muscle force measurement at the end of the rehabilitation and at 6 and 12 months<br> 4. Quality of life is measured using CAT marker and mMRC at the end of the rehabilitation and at 6 and 12 months<br>