Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series

Not Applicable

Completed

• Conditions: Root Caries
• Interventions: Device: Silver Diamine Fluoride 38%

• Registration Number: NCT04370080
• Lead Sponsor: Roseman University of Health Sciences

Brief Summary

The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.

Detailed Description

The study is a prospective, single center case series. The cases were consecutive. Participation was offered to every patient who qualified based on age and the presence of an active lesion in a root surfaces, in a furcation, or under an individual crown or crown abutment for a fixed prosthesis. The study was conducted at the dental clinic of the Roseman College of Dental Medicine in South Jordan, Utah. The University of California, San Francisco protocol for applying topical silver diamine fluoride was adapted for use with these patients. Lesions were flushed with water and then dried with compressed air, isolated with cotton rolls, and then 38% silver diamine fluoride (Advantage Arrest, Elevate Oral Care, West Palm Beach, FL) was applied repeatedly for two minutes with the manufacturer supplied dental applicator. The silver diamine fluoride was stored under the manufacturer's recommended conditions. If the patient complained about the taste, the lesion was coated with sodium fluoride varnish. All of the lesions were reevaluated for dental caries lesion activity about every six months and retreated regardless of their arrest status. Follow-up was for 30 months or until loss to follow-up.

Study Timeline

• Study Start: 2017-01-03
• Primary Completion: 2019-11-21
• Study Completion: 2019-11-21
• Status Verified: 2020-04
• Study First Submitted: 2020-04-23
• Study First Submitted QC: 2020-04-29
• Last Update Submitted: 2020-04-29
• Study First Posted: 2020-04-30
• Last Update Posted: 2020-04-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• At least 1 active root surface caries lesion by Nyvad criteria

Exclusion Criteria

• None

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Silver Diamine Fluoride	Silver Diamine Fluoride 38%	Topical application of one drop of silver diamine fluoride 38% to active untreated roof surface caries, lesions at the furcation, or lesions at crown margins. Application was repeated once each six months.

Primary Outcome Measures

Name	Time	Method
Dental caries lesion activity 1	6-12 months	Nyvad score based on visual/tactile examination
Dental caries lesion activity 2	<6 months	Nyvad score based on visual/tactile examination
Dental caries lesion activity 3	12-18 months	Nyvad score based on visual/tactile examination
Dental caries lesion activity 4	18-24 months	Nyvad score based on visual/tactile examination
Dental caries lesion activity 5	24-30 months	Nyvad score based on visual/tactile examination

Secondary Outcome Measures

Name	Time	Method
Caries lesion fluorescence 4	18-24 months	Laser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 1	<6 months	Laser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 3	12-18 months	Laser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 5	24-30 months	Laser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 2	6-12 months	Laser fluorescence measurement at the surface of the lesion