Impact of a 4 Months Training Intervention on Exercise-induced Changes of Heart Health-related Epigenetic Markers in Healthy, Sedentary Individuals
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Sedentary Behavior
- Sponsor
- Paracelsus Medical University
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- miRNA expression response to acute all-out exercise (ergometry)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
We aim to analyze the impact of a single acute exercise intervention (ergometry) on the expression pattern of specific heart health related miRNAs in healthy, previously sedentary participants, and how this pattern will be changed after 4 months of increasing the weekly physical activity >150 minutes.
Detailed Description
Exercise induced changes in heat health related miRNA expression pattern are analyzed in plasma samples collected at rest and immediately after the completion of an all-out ergo spirometry test, conducted during the baseline examination. Additionally participants will perform a pulse wave analysis to evaluate their arterial stiffness, a bioimpedanzanalysis to evaluate their body composition, blood lipids will be measured as well as their exercise capacity. After the baseline examination, all participants will perform once per week a supervised endurance and strength training at our facility. In addition, the participants will be provided with a digital application for planning and documentation of their home based physical activity. Together with an expert, they plan their weekly physical activities so that they reach 150 min of physical activity each week over a period of 4 months. After this training/exercise intervention all participants will perform all measurements from the baseline examination again.
Investigators
Prof. Josef Niebauer M.D., Ph.D., MBA
Prim. Univ.Prof.Dr.Dr. Josef Niebauer, MBA
Paracelsus Medical University
Eligibility Criteria
Inclusion Criteria
- •\<150min physical activity per week
- •\>18 years of age
- •male and female
- •signed inform consents
Exclusion Criteria
- •acute or chronic cardiovascular diseases, exempt arterial hypertension (systolic blood pressure \>140 mmHg and diastolic blood pressure \>90 mmHg in untreated and medical treated subjects)
- •acute or chronic lung disease
- •Alcohol (\>30g/day) or drug abuse
- •Adipositas grad 2 (BMI \>35kg/m²)
- •Orthopedic limitations to exercise capacity
- •pregnant or breast feeding women
Outcomes
Primary Outcomes
miRNA expression response to acute all-out exercise (ergometry)
Time Frame: Baseline
expression change of miRNA due to all-out ergometry at baseline
Change from baseline in miRNA expression response to acute all-out exercise (ergometry) at 4 months
Time Frame: after 4 months of exercise intervention
4 months of exercise intervention in healthy previously sedentary participants leads to a change in the acute exercise response (all-out ergometry).
Change from baseline miRNA expression at 4 months
Time Frame: after 4 months of exercise intervention
4 months of exercise intervention in healthy previously sedentary participants leads to exercise-induced changes in the cardio protective miRNA expression profiles
Secondary Outcomes
- blood lipides(Before and after 4 months of exercise intervention)
- arterial stiffness(Before and after 4 months of exercise intervention)
- Heart rate(Before and after 4 months of exercise intervention)
- digital application(4 months of exercise intervention)
- body composition(Before and after 4 months of exercise intervention)
- exercise capacity(Before and after 4 months of exercise intervention)
- body weight(Before and after 4 months of exercise intervention)