Efficacy of probiotics combined with standard topical therapy compared to standard topical therapy in atopic dermatitis : a randomised study

This study will be conducted in atopicdermatitis patients, attending Dermatology, Venereology and Leprology OPD atAIIMS JODHPUR through telemedicine or Physical OPD consultation.

Diagnosisbased on U.K. working party diagnostic criteria and patients fulfilling theselection criteria, will be recruited in the study after informed writtenconsent.  Detailed history and clinicalexamination of the selected patients will be done.Random allocation and allocation concealment will be done using Lottery method.Single blinding will be done and randomization sequence will be transferredin an opaque sealed envelope

For both thegroup SCORAD scoring will be done, Level of IL-31 will be measured to be takenas baseline value.

Group A will be treated with topicalcorticosteroid and emollient twice daily as per standard treatment protocol.

Topicalcorticosteroid will be given for maximum of 4 weeks in both the groups.

In Group A Probiotic rhamosus GG will becontinued for 8 more weeks. Total 12 weeks Probiotics Lactobacillus rhamnosusGG will be given in Group A.

 Group B willbe given topical corticosteroid (acc. to standard topical treatment protocol)-

1.Mild: SCORAD<25 / or transient eczema -topical mid potency steroid + emollientapplication twice daily

2.    Moderate: SCORAD25-50 / or recurrent eczema-topical mid potency steroid + emollientapplication twice daily

Follow up:Every 2 weeks for the first month and then monthly follow up will be done fortreatment response, number of episodes of flare up,  need for topical corticosteroid therapy forflare up and side effects related to therapy.

SCORADcalculation will be done at 0 and 12 weeks.

Level of IL-31will be done at 0 and 12 weeks.