Impact of Oocytes With CLCG on ICSI Outcomes and Their Potential Relation to Pesticide Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 633
- 试验地点
- 1
- 主要终点
- ICS outcomes of couples presenting differetn CLCG prevalence
研究概览
简要总结
Oocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a significant risk of decreased ICSI outcomes.
This retrospective study included 633 women who were part of an intracytoplasmic spermatozoa injection (ICSI) program between 2009 and 2011. The participants lived in the Picardy region of France and had been exposed to pesticides. The participants were divided in two groups based on prevalence of oocytes with CLCG (LCLCG [n= 83]: low prevalence of oocytes with CLCG under 25%. HCLCG [ n= 68]: high prevalence of CLCG over 75%). The embryological and clinical outcomes were analysed for both groups and were calculated using the difference between the two values.
详细描述
Oocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a significant risk of decreased ICSI outcomes.
This retrospective study included 633 women who were part of an intracytoplasmic spermatozoa injection (ICSI) program between 2009 and 2011. The participants lived in the Picardy region of France and had been exposed to pesticides. The participants were divided in two groups based on prevalence of oocytes with CLCG (LCLCG [n= 83]: low prevalence of oocytes with CLCG under 25%. HCLCG [ n= 68]: high prevalence of CLCG over 75%). The embryological and clinical outcomes were analysed for both groups and were calculated using the difference between the two values. The included population in the investigator's retrospective study consisted of 633 couples who attended a reproductive medical center and who were part of an ICSI program between 2009 and 2011.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •couples who attendes a reproductive medical center
- •couples that were part of a ICSI program between 2009 and 2011
- •women were normo-responders
- •female > 18 years <35 yeas old
排除标准
- •female < 18 years > 35 yeas old
- •couple with severe male infertility factors on oocyte activation and subsequent embryo development
结局指标
主要结局
ICS outcomes of couples presenting differetn CLCG prevalence
时间窗: 2years
The aim of the present study was to investigate the ICSI outcomes of couples presenting different CLCG prevalence's of retrieved oocytes (low prevalence of CLCG; fewer than 25% \[LCLCG\] and high prevalence of CLCG; over 75% \[HCLCG\]) and its correlation to pesticide exposure zones in the region of Picardy, France.
次要结局
未报告次要终点