Severity of RSV Infections in Twins

Completed

• Conditions: RSV Infection; Bronchiolitis
• Interventions: Other: Epidemiology

• Registration Number: NCT05070975
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide. Age at the time of infection, prematurity, multiparity, exposure to smoke and the level of passive immunity transmitted at birth are the main risk factors for lower respiratory infection associated with RSV. Other factors, including the innate immune response, respiratory microbiota, and intra-host viral heterogeneity, may also affect outcomes but are not fully considered in RSV infection. Exploring the impact of these factors is difficult due to the heterogeneity of the population which makes statistical adjustment difficult. Thus, twin models are useful in understanding the impact of the host on the environment, as twins often share similar exposure to infection and many risk factors, but not all are ie different prenatal and postnatal conditions, differential transfer of maternal antibodies and the genetic makeup of heterozygotes.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-09-27
• Study First Submitted QC: 2021-09-27
• Study First Posted: 2021-10-07
• Study Start: 2021-11-05
• Primary Completion: 2022-01-27
• Study Completion: 2022-01-27
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-04
• Last Update Posted: 2022-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• Twins born at Hospices Civils de Lyon in the years 2012 to 2020
• At least one twin hospitalized with positive RSV-PCR during the first year of life

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Exclusion Criteria

• Major differential underlying disease between twins
• Death of a twin before the RSV epidemic period of the first year of life
• Nosocomial infection
• Lack of understanding of the study or questionnaire by parents
• Lack of parental consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Twins	Epidemiology	Twins identified from the birth cohort (Hospices Civils de Lyon) with at least one twin hospitalized for an acute RSV-infection

Primary Outcome Measures

Name	Time	Method
Percentage of discordant twin pairs in severity of Respiratory Syncytial Virus infections.	1 day	The primary outcome measure is the percentage of discordant twin pairs of at least one severity level on the WHO (World Health Organization) scale.; The discrepancy in the level of severity is obtained by retrospective analysis of the data from the medical file.

Trial Locations

Locations (1)

Hôpital Femme-Mère-Enfant des Hospices Civils de Lyon; 🇫🇷 Bron, France