Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients

Completed

• Conditions: Patients Cannulated With Both PICC and CICC.; The Rapidly Fluctuating Hemodynamics During LT.
• Interventions: Device: PICC, CICC

• Registration Number: NCT00988871
• Lead Sponsor: National Cancer Center, Korea

Brief Summary

Background: Central venous pressure (CVP) monitoring from the peripherally inserted central venous catheter (PICC) has not often been used because of the higher inherent resistance of the PICC due to its longer length and narrower lumen. The objective of this study was to assess the reliability of the CVP measured from PICCs as a predictor of the CVP measured from CICCs in the setting of rapidly fluctuating hemodynamic conditions during liver transplantation.

Detailed Description

According to the protocol of LT in our hospital, a PICC is concomitantly inserted with the pulmonary artery catheter (PAC) and 9-Fr advanced venous access (AVA) catheter for the LT recipient at anesthetic induction. PAC and AVA catheter are usually removed on the second postoperative day, and instead the PICC is used for the postoperative infusion of prostaglandin E1 which is very irritable to small peripheral vein. So we fortunately had chance to measure the CVPs from both CICC and PICC simultaneously in the same patients.

Methods: We measured the CVPs from the CICC and the PICC simultaneously during each main surgical period of adult liver transplantation (preanhepatic, anhepatic, reperfusion, and neo-hepatic period). Data are presented as means ± standard deviation. Statistical analysis was performed using simple linear regression analysis to observe whether changes in the PICCP were paralleled by simultaneous changes in the CICCP. Bland-Altman analysis was used to determine the degree of agreement between the two devices. Analysis of variance was performed to study whether there were changes in the CVP agreement profiles in regard to the different time periods of LT. Differences were regarded as being statistically significant when p values were less than 0.05.

(This observational study has been completed already.)

Study Timeline

• Study Start: 2008-08
• Primary Completion: 2009-06
• Study Completion: 2009-06
• Status Verified: 2009-10
• Study First Submitted: 2009-10-01
• Study First Submitted QC: 2009-10-01
• Last Update Submitted: 2009-10-01
• Study First Posted: 2009-10-02
• Last Update Posted: 2009-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Adult patients who had been scheduled for elective liver transplant surgery
• Patients who had been placed with both PICC and CICC at anesthetic induction

Exclusion Criteria

• Failure to insert PICC

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Liver transplantation (LT) recipients	PICC, CICC	LT recipients who had both PICC and CICC at the same time according to the LT protocol of our hospital

Primary Outcome Measures

Name	Time	Method
PICCP: CVP measured from peripherally inserted antecubital central catheters in liver transplantation recipients	every 10 minutes during the liver transplantation
CICCP: CVP from IJV central catheters in liver transplantation recipients	every 10 minutes during the liver transplantation

Trial Locations

Locations (1)

National Cancer Center; 🇰🇷 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea, Republic of