The study of Amiodarone infusion given before surgery and its effect on ECHO change and free from irregular heart rate at discharge
Not Applicable
- Conditions
- Health Condition 1: I059- Rheumatic mitral valve disease, unspecified
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Elective Mitral valve replacement surgery will be included in this study
Exclusion Criteria
Pregnant patients
Patients with Thyroid disease
Patients with Heart rate of < 50/min
Patients with NYHA IV
Patients allergic to Amiodarone
Patients with Sick sinus rhythm
Patients with Atrioventricular block
Patients with Elevated liver enzyme levels
Patients with Serum creatinine >2 mg/dl
Receiving one or more of the following drugs: cimetidine, phenytoin, cholestyramine, and cyclosporine
Patients with Coronary artery disease
H/O Previous cardiac surgery
Patients with congenital heart diseases
Patients with LVEF < 50%
Systemic hypertension
Chronic lung disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the changes in Left atrial strain (LAS) and Proportion of Arrhythmia Free Patients at discharge between the groupsTimepoint: 7 days
- Secondary Outcome Measures
Name Time Method 1)To compare the proportion of patients with NSR at aortic cross clamp (ACC) release between the groups (number of patients with NSR and number of patients with AF) <br/ ><br>2)To compare the conversion of AF to NSR without the need for synchronised cardioversion/Defibrillation after release of ACC between the groups <br/ ><br>3)To compare the required energy and number of attempts of synchronised cardioversion/Defibrillation after release of ACC between the groups <br/ ><br>4)To compare the need for temporary pacing between the groups <br/ ><br>5)To compare the right ventricular systolic pressure (RVSP) and Pulmonary capillary wedge pressure (PCWP) between the groups <br/ ><br>6)To compare the duration of postoperative mechanical ventilation between the groups <br/ ><br>Timepoint: 7 days