Hypertonic saline in Primary Ciliary Dyskinesia: a pilot study
Recruiting
- Conditions
- Primary Ciliary Dyskinesia
- Registration Number
- NL-OMON22149
- Lead Sponsor
- VU University medical center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
* Diagnosis of primary ciliary dyskinesia
* ≥ 18 years of age
Exclusion Criteria
* Smoking
* FEV1 < 40 %.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary research question:<br /><br>-Is there a significant difference in change in the St. George’s Respiratory Questionnaire total and sub-scores (SGRQ) within intervention periods? <br>
- Secondary Outcome Measures
Name Time Method Secondary research questions:<br /><br>-Are there significant differences in change in the Quality of Life score for bronchiectasis patients score (QoL-B) , lung function, lung clearance index, respiratory culture results, inflammatory parameters in sputum and blood and exacerbation frequency?<br /><br>-What are the effect sizes of these differences in PCD patients?<br>