Effectiveness of Flax Lignan and Exercise Training for Improving Lipid Profiles
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- metabolic syndrome score
研究概览
简要总结
The purpose of our study is to use a flaxseed-based nutritional supplement in combination with exercise training (walking) for improving cholesterol levels. We hypothesize that exercise training will improve cholesterol profile and that adding supplementation with a flaxseed nutritional supplement will further improve cholesterol profile.
详细描述
Flax supplementation and exercise training each have small beneficial effects for improving blood lipid profile and reducing cardiovascular disease risk. Flax lignan, a phytoestrogen found in flaxseed is thought to be the active compound responsible for the cholesterol-lowering effect of flaxseed. Our purpose is to combine an exercise training program (walking) with flax lignan supplementation for improving blood lipid profile.
Comparisons: Walking (6 days per week) plus flax lignan (500 mg per day) compared to walking plus placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50 years or older
排除标准
- •Currently taking medication for cholesterol
- •Gastrointestinal disease
- •Females on hormone replacement therapy
- •Currently taking a flaxseed supplement
- •Currently engaged in vigorous exercise training
结局指标
主要结局
metabolic syndrome score
时间窗: 6 months
次要结局
- Total cholesterol at 2, 4, and 6 months(6 months)
- Aerobic fitness at 6 months(6 months)
- Body mass index at 6 months(6 months)
- Lumbar spine bone mineral density at 6 months(6 months)
- Whole body bone mineral density at 6 months(6 months)
- inflammatory cytokines(6 months)
- High density lipoprotein at 2, 4, and 6 months(6 months)
- Triglycerides at 2, 4, and 6 months(6 months)
- Blood glucose at 2, 4, and 6 months(6 months)
- Body composition at 6 months(6 months)
- Proximal femur bone mineral density at 6 months(6 months)
- Low density lipoprotein at 2, 4, and 6 months(6 months)
- Waist Girth at 6 months(6 months)
- Trunk fat skinfolds at 6 months(6 months)