A Clinical Follow-up Study of Heart Failure Patients.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- NYHA functional class
研究概览
简要总结
Heart failure (HF), a current worldwide pandemic with an unacceptable high level of morbidity and mortality, brings an enormous medical and societal burden. Chronic HF is characterized by progressive alteration of cardiac structure and function. But the molecular mechanism of these alterations is still not well-established and needs to be discussed further. HF is a highly heterogeneous disease that can be caused by a multiple of diseases. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are the main causes of this syndrome. Although HF is the common manifestation of DCM and ICM, the etiology and pathogenesis are different. Understanding the different pathophysiological mechanisms will contribute to the prevention and individualized therapy of heart failure. Therefore, this study aims to observation the different characteristics of the molecular biology and clinical courses in DCM and ICM patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •LVEF≤ 55%
- •enlarged left ventricular end-diastolic dimension
- •ICM group: with history of MI or revascularization; ≥ 75% stenosis of LM or proximal LAD; ≥ 75% stenosis of two or more epicardial vessels.
- •symptomatic heart failure
排除标准
- •Known malignant tumour diseases
- •Pregnancy or lactation period；
- •Investigators think not suitable to participate in this trial.
结局指标
主要结局
NYHA functional class
时间窗: one year after enrolled
NYHA cardiac functional class
All-cause mortality
时间窗: one year after enrolled
All-cause mortality during follow-up
次要结局
- left ventricular end-diastolic dimension(LVEDD) dilates.(one year after enrolled)
- left ventricular ejection fraction reduces(one year after enrolled)
- hospitalization for cardiac causes(one year after enrolled)