A study done to evaluate the usefulness of changes in a non- invasive parameter called End Tidal Carbon Dioxide after giving fluid infusion to neurosurgery patients to predict whether they will respond with an increase in cardiac output
Not Applicable
- Conditions
- Health Condition 1: G968- Other specified disorders of central nervous system
- Registration Number
- CTRI/2024/01/061105
- Lead Sponsor
- Dr. Anjali R Hegde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA I & II patients
2.Patients aged above 18years
3.Patients undergoing neurosurgery in supine position under general anaesthesia
Exclusion Criteria
1. Patients with cardiac arrhythmias, valvular heart diseases or left or right heart failure
2. Patients with chronic obstructive pulmonary disease with a MMRC Dyspnea Scale 3 or more
3. Patients with intrathoracic lesions
4. Pregnant women
5. Patients on vasoactive drugs
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in End tidal carbon dioxide after volume expansion to predict fluid responsiveness defined as fall in Pleth Variability Index to less than 14 percent and increase in SBP by 10 mm Hg or moreTimepoint: Baseline, 1 min, 3 min, 5 mins and 10 mins after completion of infusion.
- Secondary Outcome Measures
Name Time Method Pleth Variability Index and Pulse Pressure VariationTimepoint: Baseline, 1 min, 3 min, 5 mins and 10 mins after completion of infusion.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link end tidal CO2 changes to fluid responsiveness in neurosurgery patients?
How does end tidal CO2 monitoring compare to other hemodynamic parameters for predicting fluid responsiveness in supine neurosurgery patients?
Which biomarkers correlate with end tidal CO2 variations during volume expansion in central nervous system disorder patients?
What adverse events are associated with fluid infusion in neurosurgery patients and how can they be managed using end tidal CO2 monitoring?
Are there alternative non-invasive techniques to end tidal CO2 for assessing fluid responsiveness in central nervous system surgeries?