Efficacy of methoxyflurane inhaler to analgesia during genicular nerve block in osteoarthritis knee; a randomized control trial
Phase 2
Completed
- Conditions
- 35-85 year-old patients with osteoarthritis knee (Kellgren-Lawrence grade 3-4) who had intractable pain more than 3 months and failure to conservative treatments.methoxyflurane, osteoarthritis knee, genicular nerve block
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
1. Age 35-85 years old
2. Severe OA knee (KL III-IV) with chronic knee pain > 3 mo.
3. Failure to conservative treatments including physical therapy and non-opioid analgesics
4. Ability to use methoxyflurane inhaler
Exclusion Criteria
1. Refusal patients
2. BW < 45 kg
3. Allergy to any study medication (fluorinated anesthetics, lidocaine, steroid)
4. Personal or family history of malignant hyperthermia
5. Cardiorespiratory disease e.g. arrhythmia, ischemic heart disease, chronic lung disease
6. Hepatic/renal dysfunction
7. Seizure disorder
8. Uncontrolled bleeding disorder
9. Poorly controlled psychiatric condition including active substance use disorder and personality disorder
10. Un-cooperated patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pain score during genicular nerve block a 0-10 verbal numerical rating scale
- Secondary Outcome Measures
Name Time Method Anxiety level post genicular nerve block Thai State-Trait Anxiety Inventory from Y-1,Maximal sedation level during vehicular nerve block Pasero Opioid-Induced Sedation Scale (POSS),Adverse events e.g. hypertension, tachycardia, desaturation and dizziness during geniular nerve block Number of patients,functional limitation and satisfaction 1-month follow-up Patient Global Impression of Improvement,Behavioral pain during genicular nerve block Critical care pain observational tool