Prediction of Long-term Survival and Chemotherapy Benefit in Elderly Advanced Gastric Cancer Patients Based on the mCNS Model of Nutritional Control State Score and Sarcopenia.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,436
- 试验地点
- 1
- 主要终点
- 5-Year Overall Survival
研究概览
简要总结
This study aims to develop and validate a Nomogram (mCNS) model for predicting long-term survival in elderly patients following curative resection for advanced gastric cancer. The study is a retrospective multi-center analysis involving 924 gastric cancer patients treated at the Department of Gastrointestinal Surgery of the Affiliated Union Hospital of Fujian Medical University between 2009 and 2013, and 512 patients aged 65 and above who underwent gastric resection at the Affiliated Zhongshan Hospital of Dalian University between 2011 and 2018. An online prognostic tool is introduced to assist clinicians in predicting patient prognosis and customizing treatment and follow-up strategies.
详细描述
Data were collected from 1436 gastric cancer patients, of which 555 elderly patients with advanced gastric cancer were ultimately included after applying exclusion criteria. Patients were divided into training and testing cohorts from the Fujian Medical University Affiliated Union Hospital and Dalian University Affiliated Zhongshan Hospital. The study was approved by the institutional review boards with a waiver of informed consent due to the use of anonymized secondary data. The analysis utilized the Cox proportional hazards model to select key variables for predicting overall survival (OS). The study also implemented rigorous data handling procedures, including multiple imputations for missing data. The development of an online prognostic tool based on the Nomogram model is part of the project, designed to provide real-time survival predictions through a user-friendly interface for clinical application.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed as primary gastric adenocarcinoma by preoperative gastric endoscopy pathology;
- •Underwent R0 laparoscopic radical gastrectomy for gastric cancer;
- •Pathological stage T2-4a-N+;
- •Age ≥ 65 years.
排除标准
- •Pathological stage T1 and T2N0;
- •Age < 65 years;
- •Presence of peritoneal or distant metastasis confirmed before or during surgery;
- •Received neoadjuvant chemotherapy before surgery;
- •Remnant gastric cancer;
- •Emergency surgery or palliative exploratory surgery;
- •Preoperative abdominal CT scan not available or preoperative examination time > 1 month;
- •Survival time less than 1 month;
- •Incomplete clinical and pathological data.
结局指标
主要结局
5-Year Overall Survival
时间窗: 5 years or 60 months.
The proportion of patients who are alive at five years after treatment for elderly gastric cancer patients.
次要结局
- 1-Year Overall Survival(1 years or 12 months.)
- 3-Year Overall Survival(3 years or 36 months.)
研究者
Chang-Ming Huang, Prof.
Professor
Fujian Medical University