Neural Mechanisms of Muscle Control in Individuals With Knee Pain
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Pain reduction measured using a visual analog scale (VAS) for knee pain
研究概览
简要总结
This is a randomized controlled trial of knee muscle versus hip muscle strengthening for Patellofemoral Pain Syndrome.
详细描述
Rationale: Two prior randomized controlled trials (RCT) have highlighted the importance of hip muscle activation and strengthening as a treatment strategy for patellofemoral pain (Khayambashi, 2014; Khayambashi, 2012). Here, we propose a pilot study to acquire preliminary data to power a larger study to reveal the neural mechanism underlying the effectiveness of this intervention to promote its evidence-based incorporation into clinical practice.
Intervention: 4 weeks of quadriceps muscle versus 4 weeks of hip strengthening exercises.
Purpose: To determine changes in brain functional connectivity related to pain reduction induced by the strengthening exercises.
Study population: Males and females with a history of unilateral knee pain.
Methodology: Functional magnetic resonance imaging (fMRI) will be used to quantify functional connectivity of brain regions related to hip muscle activation. Functional connectivity will be quantified before (pre) and after (post) 4 weeks of quadricep or hip muscle strengthening exercises.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pain located specifically around the patellofemoral articulation (vague or localized).
- •Readily reproducible pain (3 out of 10 on a visual analog scale) with at least 2 of the following functional activities commonly associated with PFP: stair ascent or descent, squatting, kneeling, prolonged sitting, or isometric quadriceps contraction.
- •Reports of pain greater than 3 months duration.
排除标准
- •Previous history of knee surgery.
- •History of traumatic patellar dislocation.
- •Neurological involvement that would influence gait.
- •Contraindications to MR imaging: implanted electronic devices (i.e. pacemaker), or metallic implants (i.e. aneurysm clips, fixation screws).
结局指标
主要结局
Pain reduction measured using a visual analog scale (VAS) for knee pain
时间窗: 4 weeks and 6 months
Compared to baseline
次要结局
- Brain function measured using fMRI(4 weeks)
- Muscle activation assessed with electromyographic (EMG) recordings(4 weeks)
- Knee kinematics assessed with 3-dimensional motion capture(4 weeks)
研究者
Jason Kutch
Assistant Professor
University of Southern California