ramosetron vs. ondansetron after craniotomy
Not Applicable
Completed
- Conditions
- Certain infectious and parasitic diseases
- Registration Number
- KCT0000320
- Lead Sponsor
- Seoul National University Bundang Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
1) patients scheduled to be performed craniotomy
2) aged 19-65
3) American Society of Anesthesiologist class I-II
4) informed consent
Exclusion Criteria
1)Scheduled to be sedated after craniotomy, or unable to communicate after surgery
2)Glasgo Coma Scale < 9
3)IICP = 15 mmHg
4)Reoperation
5)Gastric disease
6)Pregnancy, antidepressant medication
7)Anticancer chemotherapy, chronic opioid use
8)Chronic nausea and vomiting symptom, antiemetics use within 24 h
9)Allergy or contraindication to study medication
10)Severe renal (Serum Cr > 1.6 mg/dl) , or hepatic insufficiency (liver enzymes more than 2 times normal value)
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method nausea;nausea numerical rating scale (NRS);retching;vomitting;need of antiemetics
- Secondary Outcome Measures
Name Time Method patient controlled analgesia (PCA) consumption;itching