Risk Factors for Postoperative Spinal Epidural Hematoma Following Posterior Thoracic Spinal Surgery in a Single Institute
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Cerebrospinal fluid leakage
研究概览
简要总结
This is a retrospective, observational single-center study. The studies is to investigate the incidence of posterior epidural spinal hematoma(PSEH) and recognize the risk factors for it in a cohort of patients undergoing posterior thoracic surgery in isolation.
详细描述
The study enrolled patients from January 2010 to December 2019, patients who developed PSEH after posterior thoracic surgery and underwent the hematoma evacuation. For each PSEH patients, 2 or 3 controls who did not develop the PSEH, underwent the same procedures of similar complexity at the same section of thoracic spine in the same period were collected. The preoperative and intraoperative factors, blood pressure related factors and radiographic parameters were collected to identify possible risk factors by comparing between two groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects satisfying the following criteria will be considered eligible for enrollment in this study:
- •Patient is ≥ 18 years and < 80 years of age;
- •Patient who received thoracic decompression surgery via posterior approach
- •Patient who diagnosed as symptomatic spinal epidural haematoma and received revision surgery.
排除标准
- •Thoracic spinal stenosis caused by trauma, tumor, infectious, deformity and other disease;
- •Symptomatic spinal epidural haematoma happened at cervicothoracic and thoracolumbar junction;
- •Initial surgeries were performed at other hospital;
- •Incomplete clinical data.
结局指标
主要结局
Cerebrospinal fluid leakage
时间窗: 6 months
Cerebrospinal fluid leakage provides internal pressure for the dura and its own contents, and a small haematoma does not easily induce symptoms. It is the author's hypothesis that if cerebrospinal fluid leakage occurs intraoperatively, internal pressure loss, even in a small hematoma, can cause compression. Therefore, cerebrospinal fluid leakage are considered as a risk factor for symptomatic spinal epidural hematoma
High occupying ratio of cross-sectional area
时间窗: 6 months
Severe compression on spinal epidural venous plexus lead to poor elasticity of the vessel wall and impedance of blood flow. As a result, dilatation of the spinal epidural venous plexus are more often in symptomatic spinal epidural haematoma patients, contributing to the development of haematoma. Therefore, high occupying ratio of cross-sectional area is considered as a risk factors for symptomatic spinal epidural hematoma.
Large local kyphosis angle
时间窗: 6 months
The local kyphosis angle was determined by the measurement of the Cobb angle. Large local kyphosis angle creates a narrow space between the paravertebral muscles and spinal cord, especially in muscles with edema after surgery. Large local kyphosis angle is considered as a risk factor for symptomatic spinal epidural hematoma
次要结局
未报告次要终点
研究者
Li Weishi
Director of the orthopaedic department
Peking University Third Hospital