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临床试验/CTRI/2022/11/047701
CTRI/2022/11/047701已完成不适用

A Randomized Controlled Trial to compare the conventional and revised anatomical landmarks for ultrasound guided cooled radiofrequency ablation of genicular nerves in patients with chronic knee osteoarthritis

Lady Hardinge Medical College1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2022年11月30日最近更新:

试验速览

阶段
不适用
状态
已完成
入组人数
90
试验地点
1
主要终点
Difference in the median Oxford Knee Score

研究概览

简要总结

Knee osteoarthritis is one of the most common degenerative conditions in the elderly age group. The definitive treatment is knee replacement surgery, but most of the patients will not be fit for surgery. Minimally invasive procedures like radiofrequency ablation of genicular nerves around the knee joint is a successful alternative for surgery. Cooled Radiofrequency ablation is a new modality that effectively ablates the genicular nerves. Previously it was done under fluoroscopy guidance but ultrasound guidance has better advantages of being radiation free and accurate capturing of nerves. Previous landmarks that have been used for ultrasound guided ablation did not cover the entire nerves, thus providing less pain relief. Recently developed revised anatomical landmarks effectively block the genicular nerves and provide better pain relief than conventional technique.

研究设计

研究类型
Interventional
分配方式
Computer generated randomization
盲法
Participant and Outcome Assessor Blinded

入排标准

年龄范围
40.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • Patients with symptomatic knee osteoarthritis graded II,III&IV according to the Kellgren-Lawrence system.

排除标准

  • Pain and functional limitations due to rheumatoid arthritis, gout and psoriatic arthritis.
  • Active infection of knee joint
  • Patients receiving any other invasive treatment for knee osteoarthritis.

结局指标

主要结局

Difference in the median Oxford Knee Score

时间窗: after 1, 4 and 12 weeks

次要结局

  • Median Numerical Rating Scale (NRS)(after 1, 4 and 12 weeks)
  • Proportion of patients developing skin burns, hematoma and numbness(immediately and within 1 week)

研究者

申办方类型
Government medical college

研究点 (1)

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