The effect of handgrip exercise on the prevention of ischaemia-reperfusion injury: a pilot study

• Conditions: Ischaemia reperfusion injury; vascular damage; 10047079

• Registration Number: NL-OMON56947
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- Adults >18 years, <64 years.
- BMI < 30kg/m2
- Recreational athlete (i.e. minimal 1h/week exercise, maximal 5 days/week of
exercise)
- Mentally able/allowed to give informed consent.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Presence of an absolute contra-indication for the performance of exercise
(see also SOP Inspanningstest Department of Physiology):
- Acute myocardial infarction (3-5 days)
- Unstable angina
- Uncontrolled arrhythmias causing symptoms or hemodynamic compromise
- Active endocarditis
- Acute myocarditis or pericarditis
- Symptomatic severe aortic stenosis
- Uncontrolled heart failure
- Acute pulmonary embolus or pulmonary infarction
- Thrombosis of lower extremities
- Suspected dissecting aneurysm
- Uncontrolled asthma
- Pulmonary oedema
- Respiratory failure
- Acute noncardiopulmonary disorder that may affect exercise performance or be
aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
- Mental impairment leading to inability to cooperate
- Use of medication that alters the effect of cardioprotection:
• β-blockers
• Calcium Channel blockers
• Nitrates
• Opioids
• Anti-platelet agents (e.g. paracetamol)
• Statins and anti-hyperlipidaemic drugs
• Anti-diabetic treatment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in endothelial function (measured with flow-mediated dilation) before<br /><br>and after IR injury (induced by 15-minute ischemia to the forearm, followed by<br /><br>20 minutes of reperfusion)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The reduction of cardiac injury via the transfer of humoral cardioprotective<br /><br>agents in ex vivo models of ischemia-reperfusion.</p><br>