Breath Volatile Organic Compounds Patterns of Lung Transplant Patients With Chronic Lung Allograft Dysfunction
Completed
- Conditions
- Chronic Lung Allograft Dysfunction (CLAD)
- Interventions
- Other: Collection of exhaled breath volatile organic compounds
- Registration Number
- NCT02836938
- Lead Sponsor
- Prof. Dr. Jens Hohlfeld
- Brief Summary
It's the aim of this study to clarify, whether the non-invasive assessment of breath can serve as a novel clinical tool to assist in the diagnosis of CLAD. If different stages of BOS can be discriminated by the level of certain VOCs than there would also be a potential to actually predict the development at an early stage and would enable an earlier intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
- Outpatient bilateral lung transplant recipients including combined transplants
Exclusion Criteria
- Active Smoking Oxygen therapy Infection with multi or pan-resistant bacteria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Severe Collection of exhaled breath volatile organic compounds Severe chronic lung allograft dysfunction (CLAD), bronchiolitis obliterans syndrome (BOS), stage 3 Control Collection of exhaled breath volatile organic compounds Bronchiolitis obliterans syndrome (BOS), stage 0 Mild Collection of exhaled breath volatile organic compounds Mild chronic lung allograft dysfunction (CLAD), bronchiolitis obliterans syndrome (BOS), stage 1-2
- Primary Outcome Measures
Name Time Method Concentration of exhaled breath volatile organic compounds one sample will be collected between 6 month and 20 years after lung transplantation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hannover Medical School
🇩🇪Hannover, Germany